MOTS-C 10mg | Lyophilised Powder
MOTS-c is a 16-residue peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene — the name is a contraction of mitochondrial open reading frame of the 12S rRNA, type c. It belongs to the mitochondrial-derived peptide class, alongside humanin and the small humanin-like peptides, and was first characterised in 2015.
Supplied as a lyophilised powder in a sealed single-use vial.
One handling note worth flagging: the sequence contains two methionine residues. Methionine is the residue most prone to oxidation during storage and handling, which makes this compound less forgiving than most on the catalogue. Storage guidance below reflects that.
Chemical identity
| Compound | MOTS-c |
| CAS number | 1627580-64-6 |
| Molecular formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular weight | 2174.6 g/mol |
| Residue count | 16 |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| One-letter | MRWQEMGYIFYPRKLR |
| UNII | A5CV6JFB78 |
| Genomic origin | Short ORF within mitochondrial 12S rRNA (MT-RNR1) |
| Class | Mitochondrial-derived peptide (MDP) |
Product specification
| Nominal fill | 10mg |
| Purity | ≥99% by HPLC |
| Identity confirmation | Mass spectrometry |
| Physical form | Lyophilised powder |
| Appearance | White to off-white |
| Documentation | Lot-specific certificate of analysis |
Storage and handling
Store sealed at −20°C, protected from light, moisture and air. Because of the two methionine residues, minimise headspace exposure and avoid repeated opening of the vial — methionine sulfoxide formation is the most likely degradation route and will show as a secondary HPLC peak. Equilibrate to ambient temperature before opening.
Supply and despatch
UK stock. Same-day despatch before 3pm, Royal Mail 24 Tracked.
FAQ
What does MOTS-c stand for? Mitochondrial open reading frame of the 12S rRNA, type c — a reference to where the coding sequence sits in mitochondrial DNA.
What is the sequence of MOTS-c? MRWQEMGYIFYPRKLR — 16 residues.
What is the CAS number? 1627580-64-6.
Why does MOTS-c need more careful storage than other peptides? Two methionine residues make it comparatively oxidation-sensitive. Keep the vial sealed, cold and dark, and limit air exposure.
Package Includes
1 × MOTS-C 10mg vial